Hugo Ortega writes about his experience moving over to the UMPC as his primary platform.
I tried this myself at one time, but found it impossible to do. I'm a developer and writing code on the UMPC platform doesn't work at all. Another problem is I watch TV on my desktop with Media Center and use the DVR capabilities, something you can't really do on the UMPC. The UMPC is my travel PC, or if I need to do a presentation it works well in those conditions.